Sick seas

Sick kids look sick.

Emergency physicians commonly evaluate children with fever and worry about how to best detect “occult” or “early” presentations of serious bacterial infections such as meningitis or sepsis. Laboratory testing is at times used to supplement clinical examination and physician judgment; however, the merits of such screening have long been debated and substantial practice variation remains. In this...

Sick individuals and sick populations.

Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding strategies in control are the 'high-risk' approach, which seeks to protect susc...

Bounded seas

Imprecise manipulation of source code (semi-parsing) is useful for tasks such as robust parsing, error recovery, lexical analysis, and rapid development of parsers for data extraction. An island grammar precisely defines only a subset of a language syntax (islands), while the rest of the syntax (water) is defined imprecisely. Usually water is defined as the negation of islands. Albeit simple, s...

Harvesting the Seas

Surviving the Cytochrome Seas

were an order of magnitude higher than those required In the molecular drama of apoptotic cell death, perhaps to activate caspases in cell extracts (0.2–0.5 mM). Intact there is no character stranger than cytochrome c. This cells thus seem to have a way to regulate or suppress the familiar heme protein can be transformed, in Jekyll and response to cytosolic cytochrome c. When apoptosis is Hyde ...